WebProtein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin - actin interaction. Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. WebFeb 25, 2024 · They applied it for the first time to the intestine and identified regenerating islet-derived protein 4 ( Reg4) as a novel marker for enteroendocrine cells, a rare population of hormone-producing intestinal cells [ 32 ]. Regenerative properties of the adult mammalian heart are insufficient to repair the heart post-ischemic injury.
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WebMar 21, 2024 · Cytoskeleton-associated protein 4 (CKAP4) is a non-glycosylated type II transmembrane protein that serves as a cell surface-activated receptor. It is expressed primarily in the plasma membranes of bladder epithelial cells, type II alveolar pneumocytes, and vascular smooth muscle cells. WebApr 12, 2024 · It is worth mentioning that HSP90 135, OSTF1 136, VDAC2 137, RPs 138,139, mitochondrial genes 140, Col2A1 141, and cytoskeleton-associated proteins 142,143,144, are all targets for MYC.
WebAug 21, 2024 · The cytoskeleton is a network of fibers forming the "infrastructure" of eukaryotic cells, prokaryotic cells, and archaeans. In eukaryotic cells, these fibers consist of a complex mesh of protein … WebAug 7, 2024 · Regenerative medicine represented by stem cell technology has become one of the pillar medical technologies for human disease treatment. Cytoskeleton plays important roles in maintaining cell morphology, bearing external forces, and maintaining the effectiveness of cell internal structure, among which cytoskeleton related proteins are …
WebActivity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene. It was first characterized in 1995. [5] [6] ARC is a member of the immediate-early gene (IEG) family, a rapidly activated class of genes functionally defined by their ability to be transcribed in the presence of protein ... CKAP4 as a receptor of APF plays an important role in mediating bladder carcinoma cells proliferation. Following CKAP4 knockdown, the inhibition effect of APF on T24 cell proliferation was eliminated, indicating the important role of the receptor in mediating the antiproliferation activity of APF in bladder cancer … See more Our group investigated the relationship between CKAP4/DHHC2 expression and prognosis in 416 patients with hepatocellular carcinoma (HCC) (Li et al., 2014b) (Table 2). … See more Previous studies reported that CKAP4 as an ER enriched protein could be secreted by exosomes of ovarian and colon cancer cells and detected as an exosomal protein in urine (Gonzales et al., 2009; Demory Beckler et al., 2013; … See more Although plentiful researches focused on the relationship between CKAP4 and cancer, there were also studies that showed that CKAP4 played an important role in noncancers. … See more Sufficient studies have confirmed that CKAP4 correlated with various cancers’ progress and prognosis. The formation of the xenograft tumors derived from CKAP4-depleted cells, including lung cancer cells (Kimura et al., 2016), … See more
WebIn addition, in the cytoskeleton protein gene silencing + SBA treatment groups (T10, T11 and T12), the expression of FasLG protein and membrane FADD and the activity of caspase-8 were significantly higher compared to T1, T2, T3, T4 and T9 (p < 0.05). and the expression level of cytosolic FADD and the caspase-8 protein expression was lower …
WebSep 1, 2013 · Cytoskeleton-associated membrane protein 4 (CKAP4), one kind of type II trans-membrane protein, mainly located in the endoplasmic reticulum [11], [12]. … brenda lorraine thomas charitable trust theWebCytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma. Background: Recent years have witnessed significant progress in the treatment of esophageal squamous-cell carcinoma (ESCC); however, the prognosis of ESCC is still unsatisfactory. Biomarkers are required to improve identification of high ... brenda lovelace facebookWebJun 1, 2024 · CKAP4 is a 63-kDa non-glycosylated and reversibly palmitoylated type II transmembrane protein that has been shown to anchor rough endoplasmic reticulum and microtubules in epithelial cells.5 Although CKAP4 was described as an endoplasmic reticulum–resident protein, it is also now known to be expressed on the surface of … countdown timer for facebook pageWebCytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma. Background: Recent years have witnessed significant … brenda louise hewett floridaWebSep 19, 2024 · Cytoskeleton-associated protein 4 (CKAP4; also known as p63, CLIMP-63, or ERGIC-63) is a 63 kDa, reversibly palmitoylated and phosphorylated, type II … countdown timer for fluorescentWebSep 19, 2024 · Cytoskeleton-associated protein 4 (CKAP4; also known as p63, CLIMP-63, or ERGIC-63) is a 63 kDa, reversibly palmitoylated and phosphorylated, type II transmembrane (TM) protein, originally identified as a resident of the endoplasmic reticulum (ER)/Golgi intermediate compartment (ERGIC). countdown timer for facebook 2022WebOct 25, 2010 · Deep sequencing of mutant DNA revealed a mutation located in an intron of the Mtap2 gene, encoding microtubule-associated protein 2, and levels of Mtap2 transcript were reduced in mutant testes. ... Together, these and other as yet unknown regulators bring about progressive changes in the nucleus and cytoskeleton, including desynapsis, ... countdown timer for exercise