2024 Doxorubicin induced hepatotoxicity

Doxorubicin induced hepatotoxicity

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August undefined, 2024

WebMar 16, 2024 · Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood. Here we ... WebJun 1, 2024 · The elevated liver index value indicates hepatomegaly which was confirmed by histopathological findings. The most widely accepted mechanism of doxorubicin …

Exercise Training Prevents Doxorubicin-induced Mitochondrial ...

WebDec 15, 2024 · Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study WebFeb 7, 2024 · Hepatotoxicity was induced by an intraperitoneal injection of doxorubicin, at a dose of 2 mg/kg bw/week, for seven weeks. Doxorubicin-injected rats were supplemented with thyme oil and thymol at doses 250 and 100 mg/kg bw, respectively, four times/week by oral gavage for the same period. ottogi oriental supermarket

New molecular and biochemical insights of doxorubicin …

WebMay 15, 2012 · Acute and subacute hepatotoxicities were analyzed with or without lovastatin co-treatment. Lovastatin protected the liver against doxorubicin-induced acute pro-inflammatory and pro-fibrotic stress responses as indicated by an attenuated mRNA expression of tumor necrosis factor alpha (TNFα) and connective tissue growth factor … WebAug 25, 2016 · Doxorubicin: 30 mg/m 2 IV: ... Refer to UpToDate topics on prevention of chemotherapy-induced nausea and vomiting in adults. Hydration: Due to the potential for nephrotoxicity associated with cisplatin, pretreatment hydration with 1 to 2 liters of fluid is recommended prior to cisplatin administration; adequate post hydration and urinary … WebFeb 7, 2024 · Hepatotoxicity was induced by an intraperitoneal injection of doxorubicin, at a dose of 2 mg/kg bw/week, for seven weeks. Doxorubicin-injected rats were … otto gioielli padova

Doxorubicin - StatPearls - NCBI Bookshelf

Doxorubicin induced hepatotoxicity

Preventive and therapeutic use of herbal compounds against doxorubicin …

WebThe results suggested that the metabolic perturbations in rats with doxorubicin induced hepatotoxicity were mainly involved in amino acid metabolism, lipid pathways, purine … WebPubMed

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WebApr 7, 2024 · This present study investigated the protective effects of asperuloside (ASP) against cadmium-induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and CdCl 2 (5 mg/kg, p.o., once daily) during the last 4 weeks of ASP treatment. The serum levels of blood urea nitrogen (BUN), creatinine (Scr), aspartate … WebApr 7, 2024 · Human colon microbiota produce a metabolite called urolithin A (URO A) from ellagic acid and linked compounds, and this metabolite has been demonstrated to have antioxidant, anti-inflammatory, and antiapoptotic activities. The current work examines the various mechanisms through which URO A protects against doxorubicin (DOX) …

WebJun 4, 2012 · The most common side effects of Doxorubicin include: hair loss (alopecia). Your hair may re-grow after your treatment. darkening of your nails or separation of your … WebFeb 22, 2024 · Mitochondria-dependent ferroptosis plays an important role in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity (DIC), which remains a clinical challenge due to the lack of effective interventions. Cerium oxide (CeO 2), a representative nanozyme, has attracted much attention because of its antioxidant properties.

WebMar 9, 2024 · Doxorubicin (DOX) is associated with numerous acute and chronic dose-related toxicities including hepatotoxicity. This adverse reaction may limit the use of … WebAug 8, 2024 · Doxorubicin is an antibiotic derived from the Streptomyces peucetius bacterium. It has widespread use as a chemotherapeutic …

WebApr 13, 2024 · The mechanism of DOX-induced hepatotoxicity is well known and is related to the generation of reactive oxygen species (ROS) that ultimately leads to cell death ( …

WebDoxorubicin (DOX) is a potent chemotherapy agent; however, its use may lead to cardiac, hepatic, and renal dysfunction. Kleinhovia hospita L extract contains antioxidant compounds that have been shown to reduce chemical-induced hepatotoxicity. イオン長久手WebMar 9, 2024 · Hepatotoxicity was induced by an intraperitoneal injection of doxorubicin, at a dose of 2 mg/kg bw/week, for seven weeks. Doxorubicin-injected rats were supplemented with thyme oil and... イオン長浜WebSep 15, 2024 · Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and nephrotoxicity. Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. Hepatotoxicity イオン長岡WebDec 2, 2024 · Doxorubicin is an anthracycline antibiotic extracted from the bacterium Streptomyces peucetius. Its cytotoxic effect produced by intercalating with DNA causing breakdown of DNA strand which causes cancer cell apoptosis. Despite being an effective anticancer agent it causes several crucial side effects like carditoxicity, neuropathy, … ottogi new zealand limitedWebA combination chemotherapy regimen of doxorubicin (DOX) and cyclophosphamide (CPS) is employed in treatment of several cancers such as leukemia, lymphoma, and breast … イオン鏡石ラーメンWebJun 1, 2024 · The alterations in the doxorubicin treated liver tissue include vacuolation of hepatocytes, degeneration of hepatocyte cords, bile duct hyperplasia and focal necrosis. … イオン長崎WebApr 5, 2024 · Doxorubicin (DOX), a common chemotherapeutic agent, suffers serious adverse effects including hepatotoxicity. Mokko lactone (ML) is a guainolide sesquiterpene with promising biological activities. otto gipfler