Examples of lipophilic drugs
WebDrugs that easily diffuse across cell membranes are small, non-ionized, and lipophilic (from lipo in Greek for “fat” and philos for “friendly). Larger ... Examples of drugs that are administered transdermally include nicotine … WebNational Center for Biotechnology Information
Examples of lipophilic drugs
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WebFeb 8, 2024 · Highly lipophilic drugs (e.g. fentanyl, propofol and amiodarone) are described by a three-compartment model: the central/vascular compartment; fast-equilibrating well-perfused peripheral tissue compartment; and slower-equilibrating deep tissue/adipose with lower perfusion compartment (Figure 2). WebLipophilicity, the ‘love of fat,’ and hydrophobicity, the ‘fear of water,’ are often taken as synonyms, but do not exactly describe the same property: hydrophobicity considers the interaction between the compound and water, whereas lipophilicity is a measure of the interaction with a lipid.
WebIncreased fat increases the volume of distribution for highly lipophilic drugs (eg, diazepam, ... Thus, for a given oral dose, older adults may have higher circulating drug concentrations. Important examples of drugs with a higher risk of toxic effects because of age-related reductions in first-pass metabolism include nitrates, propranolol, ... WebAs a measure of molecular lipophilicity, LogD is among the most important measurements in the drug hunter’s repertoire because it’s our control experiment (Figure 1). Like actin …
WebSep 15, 2016 · • Hydro/lipophilicity of drugs . 10 Distribution: Body composition • Age related changes in body composition: – TBW: • ~80% in newborns to 60% by 1 yr – Body fat: WebAn amphiphile (from the Greek αμφις amphis, both, and φιλíα philia, love, friendship), or amphipath, is a chemical compound possessing both hydrophilic ( water-loving, polar) …
WebEtoxadrol is lipophilic and can readily cross the bloodbrain barrier. From Wikipedia Often, amphiphilic species have several lipophilic parts, several hydrophilic parts, or several of …
WebLipophilic substances are those that do not dissolve in water, and thus have the ability to dissolve in non-polar substances. Some examples include oils, fat, hydrocarbons, and … pianka constructionWebMar 2, 2010 · In general, neonates and infants have larger distribution volumes for water-soluble drugs and smaller volumes for lipophilic drugs. For example, the volume of distribution of gentamicin is 0.5 to 1.2 L/kg in neonates and infants compared with 0.2 to 0.3 L/kg in adults (Echeverrisa). View chapter Purchase book Pharmacokinetic … pianka comfort plusWebLipophilic conjugates (LCs) of small molecule drugs have been used widely in clinical and pre-clinical studies to achieve a number of pharmacokinetic and therapeutic benefits. For … pianka flexifoam w materacuWebLipophilic, poorly water-soluble drug candidates are common outcomes of drug discovery programmes. Porter and colleagues discuss mechanisms by which lipids and lipidic … pianka porotherm dryfixWebDrugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins (simvastatin, … pianka clocheeWebDrugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins (simvastatin, … piani the exchange 106WebSince lipophilicity is a key determinant in BBB permeability, lipidization, that is, conversion of the drug moiety into a more lipophilic form by the insertion of lipophilic groups like … piani willis tower