WebConclusion: Exosomal HOTAIR promoted the progression and angiogenesis of endometriosis by regulating the miR-761/HDAC1 axis and activating STAT3-mediated inflammation in vitro and in vivo, which may provide promising treatment for endometriosis. Keywords: endometriosis, HOTAIR, exosomes, miR-761, HDAC1, STAT3, inflammation. Web15 mar 2012 · Prostate cancer cell proliferation and hypoxia-induced angiogenesis are also regulated by the SUMO pathway, through an AR-independent mechanism. ... Thus, SENP1-dependent deSUMOylation of HDAC1 reduces its deacetylase activity and repressive activity to AR-dependent transcription [41,42,43].
HDAC1: an environmental sensor regulating endothelial function
WebCerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4. Histone deacetylases inhibitors have been shown to be effective in protecting the brain from ischemic damage. Histone … Web16 mar 2024 · HDAC1 regulates the acetylation status of histones. 37 miR-34a inhibits the proliferation and chemoresistance of ovarian cancer cells by downregulating HDAC1 expression. 38 The proliferation and invasion of colorectal cancer cells can be restrained by miR-761 through targeting HDAC1. 39 In a previous report, it has been shown that … huntron protrack i
HDAC inhibitors: Targets for tumor therapy, immune
Web5 set 2024 · HDAC1 is one of the class I HDAC family that can modulate DNA-damage responses, stabilize DNA structure, and prevent tumorigenesis in vivo (Goder et al., … WebWe found that HDAC1 is hypoxia-inducible and that TSA has a potent anti-angiogenic effect, which is more evident in hypoxia-induced angiogenesis. In addition, TSA induce … WebView detailed HDAC1 Inhibitor specifications, including HDAC1 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name. indicates a highly recommended product based on customer preference. ... MS-275 is an HDAC inhibitor shown to inhibit angiogenesis and metastasis 209783-80-2 huntron flying probe