Synergistic apoptosis
WebDec 27, 2024 · As a result, the synergistic effect of Fenton-like reaction by Cu 2+ and mitochondria dysfunction by Ca 2+ in ROS generation is performed. Therefore, a TME-responsive calcium and copper peroxides nanocomposite based on one-step integration has been successfully established and exhibits a more satisfactory antitumor efficiency than … Web@article{Li2024SynergisticAO, title={Synergistic Apoptosis-Ferroptosis: Oxaliplatin loaded amorphous iron oxide nanoparticles for High-efficiency therapy of orthotopic pancreatic …
Synergistic apoptosis
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WebTo understand the mechanism underlying the synergistic effect of bortezomib on TRAIL, we examined the expression of proteins modulating cell proliferation and apoptosis. p21 … WebSep 7, 2015 · The results showed that the expression of apoptotic proteins in the combination groups was significantly higher than the single groups . 5. Conclusion. The …
WebMay 1, 2024 · Dual therapy was synergistic at all tested doses, with a dose reduction index of up to 29 for lapatinib + venetoclax compared with venetoclax alone. Notably, these agents operated together and shifted cancer cells to a pro-apoptotic phenotype, resulting in increased mitochondrial cytochrome c release and activated caspase-3-mediated cell … WebOct 8, 2024 · Consequently, the CHOP downstream targets such as phospho-JNK and death receptor 5 were also elevated, along with the cleavage of caspase-8, -3, and the ER stress-related caspase-4. Accordingly, inhibition of AMPK by compound C diminished the synergistic apoptosis induction, and elevated CHOP/GRP78 ratio by SY combined with FO.
WebThereafter, we assessed the activity of the HSP90 inhibitor, IPI-504, in an extensive panel of DLBCL cell lines. IPI-504, which interacts with the conserved ATP-binding site in both … WebApr 13, 2024 · The compound was cytotoxic in K-562 (23.57 ± 2.87 μM) and K-562R (25.80 ± 3.21 μM) cells, and a synergistic effect was observed when it was associated with …
WebSynergistic neuroprotective effect of schisandrin and nootkatone on regulating ... IL-1β, IL-6 and TNF-α were decreased. The levels of cleaved-Caspase3 and LC3-II were reduced, …
WebIt ultimately induced the activation of caspase-9, -8, and -3 and apoptotic cell death. Moreover, combination treatment with phentolamine and paclitaxel caused a synergistic apoptosis. CONCLUSIONS The data suggest that phentolamine is a … harvard mph scholarshipWebFeb 27, 2024 · Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer Xin Jin Department of Hospital … harvard mph tuitionWebSep 5, 2013 · TH-302 in combination with bortezomib (Btz) induces synergistic apoptosis in multiple myeloma cells. A, the chemical structure of TH-302. TH-302 is a nitroimidazole … harvard mpp mid careerWebApr 16, 2024 · HCC cell apoptosis was analyzed using Hoechst 33258 (a blue-fluorescent dye permeable to both living and dead cells), propidium iodide (PI, a red fluorescent dye … harvard mrna researchWebMar 15, 2024 · The cellular mechanism of PTX acting on cancer cells (including these with K-ras gene mutations) includes interfering with the dynamic balance between microtubules and tubulin dimers, arresting the cell cycle into G2/M phase, and promoting apoptosis. 24, 26, 27 BEZ235 is a dual inhibitor of PI3K/Akt/mTOR signaling pathway that down … harvard ms cse redditWebJun 14, 2024 · Mitochondrial apoptosis mainly regulates the Bcl-2 protein family [33]. Studies have shown that the higher the Bcl-2/Bax ratio is, the stronger the mitochondrial … harvard mph personal statementWeb- Enhanced apoptosis, NF-kB downregulation, p53/p21 upregulation, increased cell cycle arrest G0/G1 phase Pro-Apoptosis Synergistic Effects of Curcumin With Proteasome … harvard ms biostatistics ad gpa